Post-Doctoral Fellowship in Functional Genomics of Human Hematopoiesis at Boston Children’s Hospital and Harvard Medical School

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Employer: Boston Children's Hospital; Harvard Medical School
Location: United States
Publication date: 13 Sep 2017
The Bauer laboratory seeks highly motivated post-doctoral research fellows to study the functional genomics of human hematopoiesis. We are interested to identify and explore the genetic determinants of blood cell development, homeostasis, and disease. We use molecular genetic, biochemical, and genome editing methodologies to perturb and observe blood cells. We have identified enhancer elements that are subject to naturally occurring disease associated genetic variation and are critical determinants of fetal hemoglobin level and hemoglobin disorder clinical severity. We have developed methodologies for high-throughput and high-resolution functional evaluation of coding and noncoding genetic elements. Our studies are meant to elucidate fundamental mechanisms of gene regulatory elements in their endogenous chromosomal environment and to define structure-function relationships of disease relevant protein complexes. A major motivation of our work is to translate findings into novel therapies for patients with blood disorders. Prior experience in molecular and cell biology, genetics, biochemistry, gene therapy, hematopoiesis, systems biology, structural/chemical biology, and/or bioinformatics/computational biology is highly desirable. The candidate must be independent in scientific research and writing, self-motivated, ethical, team spirited, and must have exceptional laboratory, communication, organizational, and writing skills. Available projects include: dissection of chromatin regulatory complexes to identify novel pharmacotherapies for hemoglobinopathies; investigation of novel pathways that control developmental transitions in erythropoiesis; exploration of genetic elements critical for hematopoietic phenotypes; and development of genome editing therapies for autologous hematopoietic stem cell transplantation. Interested applicants should send a CV, cover letter, statement of research interest and contact information for three references via email to Daniel Bauer, MD PhD [link to] Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA. Boston Children’s Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of Harvard Medical School. The Bauer Laboratory is also affiliated with the Dana-Farber Cancer Institute, Harvard Stem Cell Institute, and Broad Institute of Harvard and MIT. [link to]
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